The latest example is news out of the European Cancer Congress (ECC) in Amsterdam.
Roche immunotherapy drug may be ‘game changer’ in lung cancer – Reuters reported. Excerpt:
Of 53 patients with NSCLC tumours treated with the drug, 23 percent saw their tumours shrink, according to results presented at the European Cancer Congress (ECC) in Amsterdam.
But the most encouraging numbers were among smokers, where the response rate was 26 percent compared with 10 percent of patients who had never smoked, said Professor Jean-Charles Soria of France’s Institut Gustave Roussy, who led the study.
…
So they drilled down into the data more closely, separating out the 81 percent of the 53 patients who were smokers or former smokers, and the 19 percent of them who were not.
“And bingo, this is the first targeted agent (drug) that shows more activity in smokers than in non-smokers,” Soria told reporters in a briefing at the ECC.
81 percent of 53 patients? Why this awkward explanation? Why not just do the math for readers?
Yes, this is a difficult cancer to treat.
But it’s not a game.
And even sportswriters would provide more about the numbers than this story gave. Missing was any information about the degree of the response rate or tumor shrinkage. And not a word about the period of followup, leaving one to wonder whether the tumor shrinkage that was observed might be a surrogate or intermediate endpoint that doesn’t equate to a truly meaningful clinical outcome such as living better or longer.
But we can’t know that from the sparse details provided.
26% response in 81% of 53 patients who were smokers or former smokers = some tumor shrinkage in 11 people.
Maybe we should keep the gamechanger pronouncement on the sideline until we get more data or more longterm experience in more people.
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Shoutouts to @susan_bewley @drkevinknopf @MichaelBaum11 in this call for more than fawning coverage from press releases for these kinds of stories.
Also, linked history inside goes back 5 years just on Grail apparently trying to become Holy Grail. https://twitter.com/garyschwitzer/status/1408849696416841731
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