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Following the health news stream from publication to news release to media coverage

Harold J. DeMonaco is the Assistant Chief Medical Officer for Care Transitions at the Massachusetts General Hospital and a long-time contributor to HealthNewsReview.org.


Public relation word cloudIt is always interesting to see how the results of a well-designed and important study can get distorted as they flow through the media. The recent publication of Development and Validation of a Biomarker for Diarrhea-Predominant Irritable Bowel Syndrome in Human Subjects in PLOS Medicine is a great example.

Bowel disorders, especially those associated with unpredictable diarrheal symptoms, are no picnic. They are especially cumbersome when they turn from an acute episode to a chronic condition. So, it is not surprising that a “simple test” for diagnosing diarrhea-dominant irritable bowel syndrome (D-IBS) would be something the media would pay attention to. The study conclusions in this peer reviewed journal are as follows:

“In conclusion, this study validates the presence of anti-vinculin and anti-CdtB as blood based biomarkers that separate D-IBS from IBD and healthy controls using a large scale prospective multicenter trial. Anti-vinculin and anti-CdtB antibodies also appear part of the pathophysiology of post-infectious IBS and may identify a subgroup of D-IBS for directed therapies. Most importantly, this appears to be an important step in determining organic bases for IBS.”

Notice the careful language in the summary. The biomarkers, “…may identify a subgroup of D-IBS for directed therapies.” Now take a look at the news release from Cedars Sinai, the institution that holds the patent on the test.

Definitive tests for irritable bowel syndrome developed at Cedars-Sinai

New blood tests will speed up diagnosis for the most common GI disorder

The news release then goes on to note,

“Pimentel and fellow researchers studied nearly 3,000 people, comparing IBS patients to those diagnosed with inflammatory bowel disease, celiac disease and those with no GI disease. The blood tests identified the two antibodies associated with IBS — anti-Cdtb and anti-vinculin — with greater than 90 percent certainty.”

As we noted in our systematic review of this news release, the text carefully ignores many of the caveats and limitations discussed in the study itself, including the fact that the biomarkers are considerably less efficient at discerning celiac disease from D-IBS.

Our review of a CBS News story that was likely prompted by this release reflects many of the same problems, starting with the headline:

New tests offer hope for millions of patients with irritable bowel syndrome

At the end of what is close to an advertisement for the lab tests, we finally get some measure of clarity:

“CBS News chief medical correspondent Dr. Jon LaPook, who is also a practicing internist and gastroenterologist, points out that the test is not perfect. While a positive test result is highly suggestive of IBS, only 44 percent of patients with IBS tested positive, meaning that many people who test negative could in fact still have the condition.”

Perhaps I should not be surprised. After years of reviewing how the media reports on medical issues for HealthNewsReview.org, I have come to expect this kind of coverage. Wildly inflated headlines designed to grab your attention, incomplete reviews of the research, and then — if you are lucky — a brief clarifying statement at the very end of the story.

I think we can do better than this. And with HealthNewsReview.org’s new funding and capabilities, we are now in a position to patrol the health news stream along its winding course like never before. We can point out where the stream is getting polluted and identify opportunities to clean it up.

Ultimately, the goal is a better, more informative health news product for the millions who drink from these waters.

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Comments (3)

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Kristin

May 22, 2015 at 1:30 pm

To be fair, the lead author of this study did say, “Since not all D-IBS subjects test positive for these biomarkers, it is also possible that these antibodies identify a subgroup of IBS for which a mechanism and therapies could be developed,” they wrote (44 percent of the IBS patients in their sample tested positive)”
http://www.medicaldaily.com/blood-test-certain-forms-irritable-bowel-syndrome-may-have-just-been-discovered-334596

    Gary Schwitzer

    May 22, 2015 at 1:54 pm

    Kristin,

    Thanks for your note, but you linked to a story by Medical Daily. We were discussing a news release from Cedars-Sinai and a news story by CBS, not by Medical Daily. Our guest blogger noted the careful language of the study authors. It was the news release language, and the ensuing CBS news language that he questioned.

    Gary Schwitzer
    Publisher

Archelle Georgiou

May 26, 2015 at 12:53 pm

So glad that you called foul on this CBS story. I spoke to the lab company who performs this test (Commonwealth Laboratories) and expressed my concern that they made sweeping comments about the value of IBSchek (the name of the test) for all IBS sufferers but didn’t clarify that the study only measured its value in diarrhea predominant IBS (which is only 30% of cases. In fact, I verified (because I just couldn’t believe it!) that the study design didn’t even include an arm with non-diarrhea predominant IBS. So…bottom line…if a general population of IBS patients (who are constantly searching for answers) get this test (which costs $199)…70% of them will not be able to have any interpretation of their results because there is no science to back it up. The company said those results would be coming out later in the year. I covered this debacle on KSTP on Sunday night: