In need of scrutiny: Misleading stem cell claims by academic medical centers

Mary Chris Jaklevic is a freelance health care reporter and regular contributor to this blog. She tweets as @mcjaklevic.

While there has been significant news media coverage of proprietary clinics that hawk unproven stem cell “treatments” to vulnerable patients, much less attention has been paid to misleading stem cell claims made by elite academic medical centers.

misleading stem cell claims

These academic medical centers promote stem cell therapies that haven’t been proven to work.

Marketing messages of some top research institutions strongly suggest that certain stem cell therapies benefit patients, when in reality they haven’t been proven to work.

“There’s a misconception that those are not the organizations we need to worry about” when it comes to stem cell hype, said Leigh Turner, PhD, a University of Minnesota bioethicist. “We need to urge people to think critically about all sources of information.”  

‘Feeling quite well, more active and more peppy’

Take a video on the Mayo Clinic website entitled “Stem Cell Heart Repair.” It promotes a therapy for advanced heart failure, a serious condition affecting millions of Americans. Using stem cells to fix weak hearts isn’t a proven treatment. In fact, a clinical trial showed this procedure doesn’t work. Yet the video’s narrator states:

“If only doctors could help many of these hearts repair themselves. Thanks to a breakthrough in stem cell technology, that dream is becoming reality.”

As “living proof,” the video shows a Serbian man who attests to “feeling quite well, more active and more peppy” following treatment he received as part of a clinical trial. Says the narrator: “All of the patients in the recently completed C-CURE trial who had these cells injected into their diseased hearts showed improvement.”

The video caught the eye of Jonathan Kimmelman, PhD, a biomedical ethicist at McGill University, who tweeted about it last week.

That tweet drew a string of amens, including this from Jeremy Snyder, PhD, an associate professor of health ethics at Simon Fraser University in British Columbia.

Steve Joffe, MD, an associate professor in medical ethics at the University of Pennsylvania Perelman School of Medicine, posted a link to a similar example.

That video promotes stem cell therapies for autoimmune conditions under study at Northwestern University Medical Center, although it’s posted on YouTube, not on the Northwestern website.  A variety of ethical concerns around those trials–including that patients have been encouraged to raise money to fund their own participation–were chronicled in detail by stem cell researcher Paul Knoepfler on his blog.

Boosterish videos lack needed cautions

In another example pointed out by Turner, the University of California at Davis posted this boosterish video profiling a woman who participated in a stem cell trial to regenerate blocked blood vessels. Her story also was shared by The Sacramento Bee, as an example of how UC Davis has become a “key player in stem cell research.”

All of these promotional videos are more than a year old, yet linger in the public domain. They put forth individual patient stories as evidence that stem cell therapies work, backed up by researchers delivering scientific explanations. But they don’t balance those upbeat and authoritative-sounding messages with cautions about uncertain effectiveness, nor mention institutional conflicts of interest, such as the financial stake that Mayo and the researcher who appears in its video have in the heart failure therapy.

Ethicists point out that there’s a lot wrong with academic medical centers trying to puff up their brands with stem cell trials. “A core commitment of academic institutions is to generate the evidence that underpins medical treatment and to share that evidence with peers, patients and the public. When academic institutions make public claims that go way beyond what the evidence supports, they undermine their core mission,” Joffe wrote in an email.

Portraying of these procedures as therapeutic could lure patients into clinical trials with the false belief they are receiving a proven treatment.

“When it’s framed as an effective therapy, the message seems to be, with a wink, ‘Sure, it’s a clinical trial, but this will help you.’ That’s not an accurate claim,” Turner said.

Reputable institutions also risk validating the idea that stem cells are an all-purpose miracle cure, which can drive desperate patients to undergo bogus procedures at proprietary clinics with no ethical safeguards.

Encouraging ‘unrealistic expectations’

Resources for balanced information

There are sources where consumers can turn for balanced information on stem cell treatments, including the websites of some academic medical centers. The International Society for Stem Cell Research provides patient resources. offers tips for journalists to combat stem cell hype.

Also, listen to our podcast on stem cell hype.

“When you have not just the charlatans in the strip mall but researchers at highly regarded medical centers making claims ahead of the evidence, that’s encouraging patients and their families to have unrealistic expectations about the clinical value of these treatments,” Kimmelman said.

In fact, therapies based on stem cells have been proven effective for only a very few conditions.

Snyder said was particularly bothered by footage showing a Northwestern patient calling stem cell injections a “cure.”

“You’re allowing the patient testimonial to make claims you wouldn’t make yourself. You’re essentially allowing the patient to do that on your behalf, and I think that’s really slimy,” he said. Read why “cure” is one of our 7 words you shouldn’t use in medical news.

Northwestern did not reply to a request for comment.

Mayo Clinic spokeswoman Angela Bingham said in an email that the heart failure video “is a Mayo Clinic media resource intended to share information with the public on research in regenerative medicine and science and on the potential of new therapies to restore health for people with chronic conditions and degenerative diseases.”

She added, “This video is not marketing. It was Mayo reporting on the results of a study, and talking broadly about the work in this field as a result of this research.”

Where are the patients who didn’t improve?

As for the study, she sent a link to a 2013 safety study that deemed the procedure safe. However, that research was not designed to ascertain whether it improved health.

UC Davis spokesman Charlie Casey said in an email that its video “was originally produced as part of a UC Davis brand-awareness campaign several years ago. It was not–and is not–an advertisement for stem cell therapies. Rather, the video was done to celebrate one success, and obviously the hope for more.” 

He added, “This one patient’s story is evidence of the efficacy of UC Davis’ expertise in the case of that one single patient. And it is a good way to highlight the type of innovative research and clinical care that takes place at UC Davis Medical Center.”

But as ethicists pointed out, these portrayals offer a lopsided view that certainly feels promotional in nature. Where are the patients who didn’t improve? And how do we know a patient’s progress is the result of a stem cell injection? Unless it’s been proven to work in a clinical trial, we don’t.

Academic medical centers “should be careful they are not feeding into the hype,” said Snyder, who thinks relying on potentially cherry-picked patient stories is especially hazardous. “We do know that these patient testimonials are really effective to get patients to hand over money to participate in stem cell treatments. If their purpose is to accurately convey information, then the use of a patient testimonial is really troubling.”


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Comments (1)

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Lynn O'Donnell

November 22, 2017 at 12:25 pm

It appears Mayo may have taken their video down.