The very preliminary study mentioned in this news release relies on only 12 cancer patients filling out an unvalidated questionnaire about whether taking lactoferrin supplements improved their sense of taste and smell.
This is a weak news release about a weak observational study because it provides no supporting data, never mentions how small the study is, and doesn’t explain the basic design or multiple limitations of the study.
To then write a headline broadly claiming alleviation of chemotherapy side effects and state the “findings could bring relief to millions of patients undergoing cancer treatment” is a textbook example of overreaching and unjustified hype with significant potential for misleading — not “bringing relief” to millions.
What this news release does do well is establish that altered taste and smell in cancer patients is a very real problem with very real consequences. An effective therapy could help millions of people and potentially make millions of dollars for those who develop such a treatment.
Dangling headlines of false hope without supporting evidence is not just irresponsible, it’s potentially unethical.
Avoiding this egregious level of misinformation is not difficult. At the very least it could be addressed by including study results and clearly explaining to readers what the strengths and limitations of those findings are. After that, double check your headline and ask yourself: is it more eye-catching or more evidence-based?
The cost of lactoferrin supplements is not mentioned.
The 250 mg capsules used in this study were supplied by Jarrrow Formulas who list the capsule price as 50 cents. Therefore, three-a-day dosing — as tested in the study — would cost $1.50.
A study author is quoted as speculating that lactoferrin …
“elicits changes in the salivary protein profiles in cancer patients — changes that may be influential in helping protect taste buds and odor perception” — which in turn — might “reduce TSA (“taste and smell abnormalities”), restoring their ability to enjoy food during a time in which nutrition can play a key role in recovery.”
Although the logic here appears sound there is no data included to support this chain of eventualities.
No mention is made of potential harms from lactoferrin.
Readers might be curious about the potential for intoxication (animal studies have been inconclusive in this area) or intolerance.
WebMD mentions:
“Lactoferrin can cause diarrhea. In very high doses, skin rash, loss of appetite, fatigue, chills, and constipation have been reported.”
Several problems here that aren’t mentioned in the release:
Not addressing these limitations is a major weakness of this release and, therefore, a huge disservice to readers.
This news release does not disease monger. Rather, it clearly states that TSA in cancer patients is a common problem, and can be detrimental to cancer patients’ recovery.
Funding sources are excluded.
Careful review of the author disclosures included in the study reveal no significant conflicts of interest.
It’s rather misleading to claim “until now, there have been no reliable therapies” for TSA, because this study cannot establish lactoferrin as a “reliable therapy” based on only 12 patients.
Many approaches have been tried to help cancer patients cope with altered taste/smell including: dietary changes, Zinc supplementation, and agents which increase saliva production, to name a few.
It wasn’t made clear enough in the release that lactoferrin supplements are available online. Many readers might erroneously think the only source is drinking milk.
Using an agent that binds iron is not novel.
Also, the release does not make it clear if there are other agents currently being investifated that “elicit changes in the salivary protein profiles in cancer patients that may be influential in helping to protect taste buds and odor perception” as lactoferrin is postulated (but not proven) to do.
A preliminary study that relies heavily upon a highly subjective questionnaire completed by just 12 patients does NOT justify a headline/subhead like this:
“Milk protein shown to alleviate chemotherapy side effects: Findings could bring relief to millions of patients undergoing cancer treatment.”
“Our results suggest lactoferrin may be developed as an effective dietary supplement to treat TSA caused by chemotherapy and increase the expression of salivary proteins.”
This statement is barely supported by the data and the extrapolation made in the news release is completely unfounded.
Systematic, Criteria-Driven
Come on, NY Times; you must do better than this. Important research doesn’t need hype and the “breaking news” BS doesn’t help readers or patients. https://www.healthnewsreview.org/2022/03/nyt-proclaims-breaking-news/
Our editorial team was blessed to have Sharon as a contributor during our best years. As this obit states, she was “kind, patient, wise, thoughtful and generous.” Thank you, Sharon; now rest in peace. https://journalism.wisc.edu/news/in-memoriam-sharon-dunwoody-1947-2022/
We’ve written about the hype of liquid biopsies for years (see link in comment below). And now this…. https://www.statnews.com/2022/01/12/medicare-shouldnt-cover-liquid-biopsies-early-cancer-detection/
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