This news release plays up a liquid nitrogen-based procedure for treating breast cancer, called IceSense3 (ICE3). The probe is inserted into the breast via a small incision, guided into the middle of a tumor, and pumped with liquid nitrogen to freeze and kill the cancerous lesion from the inside out. This allows the body to naturally dismantle and get rid of the dead tissue — no major surgery required and it lasts less than 30 minutes, we’re told. And it’s stated (over and over again) how “minimal” the procedure is, plus the “excellent cosmetic results” it has, since it can get rid of cancers that would otherwise call for disfiguring breast surgeries and mastectomies. The technology is described as a new-and-improved version of a cryoablation method used to treat “liver, kidney, prostate and other cancers.” But the release offers no hard numbers of efficacy of those treatments, nor does it make any meaningful comparison as to how good they are compared to surgery. Unless the reader is a clinician or very well-informed patient, ICE3 could come off sounding like a magical cure-all. The reality is that no treatment is foolproof, and there are also other uncomfortable treatments that precede and/or follow surgery — radiation therapy and chemotherapy being the two principles ones. At its core, the release is a sales pitch intended to recruit women recently diagnosed with breast cancer into a clinical trial for ICE3, since how well the procedure treats breast cancer is an unknown. But the pitch falls short. Describing the efficacy of cryoablation compared to surgery, even with other types of cancers, would have made this a much stronger, more balanced, and more convincing release. So would have describing typical follow-up radiation and chemotherapy treatments.
Bowing to cosmetic appeal doesn’t necessarily save lives when it comes to breast cancer, but it matters a great deal to women diagnosed with the disease. They want to come out of their treatment feeling as whole and like themselves as possible. So, any effective and minimally invasive procedure that lowers the need for breast surgery is welcome in the suite of tools to treat breast cancer. But for better or for worse, it takes brave volunteers to prove the efficacy of such treatments.
There isn’t a dollar sign anywhere in this release, but other cryoablative therapies cost about $11,000 to $12,000 per session and multiple sessions are sometimes necessary.
The release says that “the benefits of cryoablation over traditional breast cancer surgery are significant.” And it lists many purported benefits including greater convenience, cosmetic advantages, and fewer complications. But we’re not given any hard numbers on recurrence or spread of breast cancer following an ICE3 procedure — arguably the most important outcomes. This would be difficult to report on, since the procedure is currently undergoing clinical trials to assess just that. But not including a sentence that concisely explains this is a pretty glaring omission. ICE3 is also compared to cryoablation therapy for other cancers (e.g. liver, prostate, kidney). Numbers here comparing those treatments to traditional surgery would have helped us grasp how effective the procedure might be.
The most we get is that patients felt “minimal discomfort.” But could ICE3 leave cancerous tissue behind without a clinician knowing? And are there any other side effects? We aren’t told, and this seems strange given that the “cosmetic” benefits are so well-known and touted so frequently in the text. The National Cancer Institute does describe a few potential harms of cryoablation (which they classify as a type of cryosurgery), including hemorrhaging and bad interactions with chemotherapy. These probably should be mentioned in the release.
The release claims ICE3 could help “thousands of women” and that the clinical trial being conducted is limited to patients with a breast tumor that’s 1.5 cm wide or smaller. But it offers no other details about the nature of the trial being conducted, nor does it discuss the evidence from other studies of this approach, whether in breast cancer or in other cancers. It would have been nice, for example, to see some discussion of the difficulties in doing a randomized clinical trial of this surgical procedure. There is such a high likelihood of bias in trials of surgery that there should be something about how they would avoid that in the current (undocumented) trial. Similarly, a few words about the strength of the evidence from other trials would’ve helped ground the discussion.
There’s some strong language describing the pain and lengthy recovery of surgery, and the suffering that many women experience following surgery. But that’s not disease-mongering per se — it’s more of a way for the release to pump up the advantages of the new approach.
IceCure Medical, the manufacturer of ICE3, is named as the source of the release.
ICE3 is compared extensively to surgery, which is the leading treatment for breast cancer. However, it would have helped to put the treatment into context with preceding and follow-up treatments, including radiation and chemotherapy.
We’re told ICE3 is currently in clinical trials for treating breast cancer and is only available at 20 US sites, at least two of which are named in the release.
Breast cancer isn’t normally treated with cryoablation, and the release makes this clear. We’re also told the improvements built into ICE3 makes treating cancer with it “more precise” and reliable.
The introduction is pretty dramatic — “Imagine. A nick of the skin, a flash of cold…” — but the release crosses the line with its language about the disfiguring nature of surgery. It says women achieve “excellent cosmetic results” with cryoablation and that they are “extremely relieved to avoid painful, disfiguring surgery and long recovery times.” According to the release, it seems that the only alternative to cryoablation is disfiguring mastectomy, but there are other intermediate surgical options (lumpectomy) that minimize scarring and post-mastectomy reconstruction is available. The release should have been more tempered in its description of surgical outcomes.
Systematic, Criteria-Driven
Following a shift in journalism’s business model, a diverse ecosystem of publications, many covering science, has sprung up online. This has made it more difficult to sort out what qualifies as journalism, what doesn’t, and whether the public even cares.
https://t.co/qO2a27FiSe
Researchers and journalists do the public a grave disservice when they spin health study results to make them appear safer or more effective than warranted, says @HealthNewsRevu founder @garyschwitzer https://t.co/QIKsRbP6Ed
Comments
Please note, comments are no longer published through this website. All previously made comments are still archived and available for viewing through select posts.
Our Comments Policy
But before leaving a comment, please review these notes about our policy.
You are responsible for any comments you leave on this site.
This site is primarily a forum for discussion about the quality (or lack thereof) in journalism or other media messages (advertising, marketing, public relations, medical journals, etc.) It is not intended to be a forum for definitive discussions about medicine or science.
We will delete comments that include personal attacks, unfounded allegations, unverified claims, product pitches, profanity or any from anyone who does not list a full name and a functioning email address. We will also end any thread of repetitive comments. We don”t give medical advice so we won”t respond to questions asking for it.
We don”t have sufficient staffing to contact each commenter who left such a message. If you have a question about why your comment was edited or removed, you can email us at feedback@healthnewsreview.org.
There has been a recent burst of attention to troubles with many comments left on science and science news/communication websites. Read “Online science comments: trolls, trash and treasure.”
The authors of the Retraction Watch comments policy urge commenters:
We”re also concerned about anonymous comments. We ask that all commenters leave their full name and provide an actual email address in case we feel we need to contact them. We may delete any comment left by someone who does not leave their name and a legitimate email address.
And, as noted, product pitches of any sort – pushing treatments, tests, products, procedures, physicians, medical centers, books, websites – are likely to be deleted. We don”t accept advertising on this site and are not going to give it away free.
The ability to leave comments expires after a certain period of time. So you may find that you’re unable to leave a comment on an article that is more than a few months old.
You might also like