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Props for mostly cautious description of preliminary study on pancreatic cancer treatment

Early data shows nearly 2x prolonged median survival for inoperable pancreatic cancer

Our Review Summary

This news release reports results of a retrospective study comparing conventional radiotherapy for inoperable pancreatic cancer versus an adaptive radiation therapy that allows clinicians to see the tumor in real time and respond to changes on a daily basis. Targeting the tumor more specifically means higher doses of radiation can be used without increasing damage to surrounding tissues. The study, funded by ViewRay, maker of the MRIdian system, is admittedly preliminary. It is to be followed up by a clinical trial.

The release would have been more helpful to readers had it mentioned costs and disclosed a conflict of interest between one of the study authors and the device manufacturer.

 

Why This Matters

Surgery is an option only for certain less common types of pancreatic cancer. The five-year survival rates for pancreatic cancers that cannot be treated with surgery are 12% to 14% even for those diagnosed in stage I; the five-year survival rate for cancers detected at stage IV is about 1%, according to the American Cancer Society. ACS reminds readers that five-year survival rates are estimates and that “many people live longer – often much longer – than 5 years.”

In that context, a treatment that could extend the lives of the 1.5% of Americans who develop pancreatic cancer is big news.

Criteria

Does the news release adequately discuss the costs of the intervention?

Not Satisfactory

Costs of the MRIdian on-table adaptive radiotherapy in comparison to conventional radiotherapy are not discussed. Given that it is new and more personalized than current treatment options it’s likely to be correspondingly more expensive. Certainly, more frequent MRIs would be very costly.

Does the news release adequately quantify the benefits of the treatment/test/product/procedure?

Satisfactory

The release provides exact information about increased survival rates in the cohorts of individuals treated with the adaptive versus the convention radiotherapy techniques.

“The cohort receiving a higher dose demonstrated a near doubling of median overall survival (Kaplan-Meier estimated median overall survival of 27.8 months compared to 14.8 months).”

Does the news release adequately explain/quantify the harms of the intervention?

Satisfactory

The news release provides specific results regarding experiences of both groups with regard to toxicity from radiotherapy.

Does the news release seem to grasp the quality of the evidence?

Not Satisfactory

We appreciate that the headline of this release starts with the words “early data” because this report deals with preliminary and retrospective research. It was not a clinical trial. Instead, results are based on retrospectively comparing treatment of two groups of patients at four institutions. Respective comparisons can’t account for a host of factors that might influence results. At the end of the news  release readers are told that on the basis of these promising results a clinical trial is being planned.

Does the news release commit disease-mongering?

Satisfactory

With five-year survival rates of 1 to 14%, it would be hard to engage in disease mongering about pancreatic cancer.

Does the news release identify funding sources & disclose conflicts of interest?

Not Satisfactory

This research was sponsored by ViewRay, the company that developed the MRIdian system, and the release does a good job calling attention to this. However, according to the published study, at least one of the co-authors received honoraria from ViewRay Medical Systems. Since this was not included in the release we’re rating this criteria Not Satisfactory.

Does the news release compare the new approach with existing alternatives?

Satisfactory

This study was all about comparing alternatives, so it scores Satisfactory on that criterion. It would have helped readers if alternatives would have been described more in laymen’s terms.

Does the news release establish the availability of the treatment/test/product/procedure?

Satisfactory

The news release notes that the next step is a prospective clinical trial and that tells savvy readers that this treatment strategy has a long road of testing ahead. Still, we think the release could have done a better job clarifying that this therapy is not yet ready for patients, outside of the clinical trial.

A study that suggests a doubling of median survival is sure to capture the attention of patients newly diagnosed with pancreatic cancer. These patients and their families are closely aware of the glum statistics for the disease. This is a practical concern that the release should have touched on.

Does the news release establish the true novelty of the approach?

Satisfactory

This technology is indeed novel and unique to ViewRay, though it is becoming available in more and more cancer treatment centers.

Does the news release include unjustifiable, sensational language, including in the quotes of researchers?

Satisfactory

No unjustifiable language was identified in the news release.

Total Score: 7 of 10 Satisfactory

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