This may be a tough release for readers to sort out because, like the headline (“Yoga may lessen side effects in men undergoing prostate cancer treatment”), and the subhead (“More men willing to participate in yoga therapy than expected, Penn study finds”), the messages the release is sending out are wildly divergent, with scant evidence to back up either thesis.
At its core, the release focuses on an unpublished “feasibility study” that was presented at the recently concluded Society for Integrative Oncology annual conference. Researchers from the University of Pennsylvania School of Medicine radiation oncology department claim that levels of fatigue, sexual health, and urinary incontinence remained stable among a small group of men (27) undergoing outpatient radiation therapy who completed an intensive yoga program.
The idea that more men than expected participated in the yoga class seemingly came out of the blue. It’s unclear where that idea came from.
Just as we hold news releases to the same standards as news stories, so do we hold complementary medicine to the same standards as traditional medicine. We need facts.
Interventions, including radiotherapy, intended to treat prostate cancer often cause a host of side effects, including fatigue, impotence and urinary incontinence. If yoga were shown to alleviate those effects, that would be important information for men undergoing radiation therapy to know in making decisions about their treatment and its followup.
The news release did not say how much the yoga classes cost, but that is not a fatal flaw, given that the classes are offered daily to millions of downward dog fans in health centers, living rooms and parks around the world. We’ll rate this Not Applicable.
Numbers might have helped the reader decide whether, in fact, the news release was really about how yoga may lessen the side effects associated with prostate cancer treatment, or whether it was about the feasibility of such a study.
But numbers were lacking. “Most yoga participants reported a sense of well-being at the end of each class, and upon finishing the yoga program and concluding their study involvement, many patients requested and received an at-home practice routine to fit their needs,” one researcher says.
Most? 51%? 99%?
Measuring how someone feels is often subjective and can be difficult. In this case, yoga’s effect was measured by participants’ responses to questions about quality of life, cancer-related fatigue and the prevalence of impotence and urinary incontinence.
The comment that scores were variable but then improved suggests that they did not achieve statistical significance. Even if they did, the question would be whether the differences were considered clinically important — and how they would compare versus other interventions. There was a substantial loss to follow-up (40%), but the investigator seemed most pleased that 27 men completed the study (and that 45 out of 68 eligible men agreed to participate). We would like to have known what the criteria were for eligibility. This is where it would be be wonderful to have a study to look at. Unfortunately, we’re told only that the study will be published sometime in 2016.
The news release does not say whether anyone felt that yoga may have caused any harms. Injuries from the practice of physical yoga (as opposed to meditative) are, in fact, quite common, although most are minor and include pulled muscles and sprains but can extend to more serious injuries such as a ruptured disk in the lower back.
The study apparently did not include a comparison group of men who did not take yoga classes. Historical controls are fine when testing a treatment where the benefits are obvious, as occurred after the discovery of insulin.
But they are less helpful when trying to measure the impact of an intervention like yoga that may exert a more subtle impact on side effects, as described here in the release:
“Severity of fatigue scores demonstrated significant variability over the time of treatment, with increases by week four as expected, but then improving over the course of treatment. Erectile dysfunction, urinary incontinence, and general quality of life scores demonstrated steady trends.”
The researchers appear to be aware of a major drawback to the way the work was structured; the news release notes that “the team is randomizing prostate cancer patients to participation vs. no participation in this structured yoga program in order to further characterize the potential benefits of yoga in this population.”
And the quality of that evidence took a hit when 40% of the participants “were voluntarily withdrawn early due to unavoidable and unanticipated conflicts between radiation treatment times and the yoga class schedule.”
In other words, the validity and importance of findings are uncertain.
The news release cites American Cancer Society figures on the incidence of prostate cancer in the United States and therefore cannot be accused of disease mongering. However, a substantial proportion of men diagnosed with prostate cancer in a time of widespread use of prostate-specific antigen (PSA) testing are found to have low-risk cancers that do not likely require treatment. The best way to prevent treatment complications is to avoid unnecessary treatments.
The news release makes no mention of funding or possible conflicts of interest. It does say that the oral abstract was presented at the Society of Integrative Oncology’s 12th International Conference.
The news release does not mention any other interventions that might mitigate the side effects associated with prostate cancer treatment.
While the release mentions other services available at the cancer center — stress reduction techniques, meditation, reiki therapy — they are not presented in the context of alternatives for improving quality of life for prostate cancer patients and do seem more in line with marketing the cancer center.
Although the near ubiquity of yoga classes is well-known, it is not clear how available Eischens yoga classes may be. The release also doesn’t tell us what distinguishes Eischens yoga from other forms of yoga.
The news release said this is the first such effort to assess the potential value of yoga in this setting.
The lead sentence quotes researchers at the University of Pennsylvania stating that men with prostate cancer who are undergoing radiation therapy “can benefit from yoga.” In her closing quote lead researcher Neha Vapiwala, MD, associate professor at the University states, “We offer several ways to enhance quality of life, minimize or reduce side effects of cancer and cancer treatment, and promote healing and recovery.”
But nowhere in the news release are we given more than anecdotal evidence to support those assertions.
There was no data supporting the claim that more men than expected participated. Where did that idea come from? Given that the population was men with cancer one would expect them to be more open to alternative therapies.