Read Original Story

Anthracycline drugs may increase heart disease risk in breast cancer survivors


4 Star

Anthracycline drugs may increase heart disease risk in breast cancer survivors

Our Review Summary

This is a solid report on a controversy over potential risks of heart failure associated with a class of commonly used breast cancer chemotherapy drugs called anthracyclines. The reporter draws on a variety of sources and provides differing perspectives about risks and benefits.

However, the story is really about new understanding of which subgroups benefit from anthracyclines, not that they "work no better" than other drugs.

The article would have been stronger if it had included statistics about how effective the various cancer drugs were.

The story is made weaker, not stronger, by the anecdote at the end. The woman interviewed was an overweight smoker at elevated risk for heart disease, and we don’t know enough about her treatment to know whether anthracyclines had anything to do with her heart problems or recovery. This is at best confusing, at worst misleading.  


Does the story adequately discuss the costs of the intervention?


The article does not report how much the drugs costs, but the price is not necessary or useful in this story. The issues with both treatment and side effects are literally life and death. The relative cost of the drugs is not an issue. 

Does the story adequately quantify the benefits of the treatment/test/product/procedure?

Not Satisfactory

While the report states that the controversy is triggered by new research suggesting anthracyclines "work no better" than less risky drugs, it does not compare efficacy of the treatments directly.

The article does report that only around 8 percent of breast cancer patients would get unique benefit from the drug. This is useful, but it is not proof that anthracyclines "work no better" than the alternatives. 

Does the story adequately explain/quantify the harms of the intervention?


The story is quite clear about the nature and size of the drugs’ risks.  


Does the story seem to grasp the quality of the evidence?


The reporter cites a credible source’s analysis of nine studies that shows only 20 percent of breast cancer patients with an overactive Her2 gene respond to anthracyclines, and only 8 percent of the group gets special benefit from the drugs. (Although the reporter could have noted that the source is NOT a disinterested party – since he is discussing the findings from some of his own research.) 

The report also cites a new Journal of Clinical Oncology study that shows people who had taken anthracyclines were 26 percent more likely to have developed heart failure in the following decade. The report provides sufficient detail about the study’s methodology. 

Does the story commit disease-mongering?


The article does nothing to exaggerate the seriousness of breast cancer or heart failure, nor does it exaggerate the benefits of chemotherapy with anthracyclines or other drugs.

Does the story use independent sources and identify conflicts of interest?


The report quotes three credible sources–two researchers and one clinician. They do not appear to have conflicts of interest.

The recent study described is from a peer-reviewed journal.


Does the story compare the new approach with existing alternatives?


The article does a decent job of indicating that other chemo drugs are available. It would be useful to know a bit more about how many alternatives there are and how widely they are used.

Does the story establish the availability of the treatment/test/product/procedure?


The article states that anthracyclines are a "mainstay" and a "staple" of chemotherapy for breast cancer. While this makes clear that the drugs are widely available, it would have been useful to know what percentage of chemo patients get these drugs compared to others.

Does the story establish the true novelty of the approach?

Not Satisfactory

The story implies the side effect issue is novel, while in fact the heart-related side effects of these drugs are well-known.

Does the story appear to rely solely or largely on a news release?


There is no evidence that the article draws on a press release.

Total Score: 8 of 10 Satisfactory


Please note, comments are no longer published through this website. All previously made comments are still archived and available for viewing through select posts.