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Study suggests a second LDL test


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Study suggests a second LDL test

Our Review Summary

This brief newspaper report describes a test called the NMR LipoProfile, which is used to measure the number and size of LDL particles. The test maker says these particles provide a more accurate picture of cardiovascular disease risk than LDL numbers alone.

As the rating for this news story suggests, it falls far short of most health journalism best practices. It fails to report on price, availability, medical need, alternative approaches, related research or potential harms.  

But the story’s most serious flaw is its failure to include independent sources’ assessment of the value of LDL particles in assessing heart disease risk–and of the LipoProfile test in particular.

Depending solely on the views of the test maker’s former chief medical officer, who has collaborated in his research with a current company executive, was a bad journalistic decision.


Does the story adequately discuss the costs of the intervention?

Not Satisfactory

The article fails to report how much the test costs.

Does the story adequately quantify the benefits of the treatment/test/product/procedure?

Not Satisfactory

The article implies that people with "low" LDL particles are linked to a 27 percent reduced risk of heart attacks. But the sentence is so unspecific and garbled it’s hard to know what the claimed benefit is. And the story only gives this relative risk reduction figure, not the more helpful context of the absolute risk reduction.  

Does the story adequately explain/quantify the harms of the intervention?

Not Satisfactory

The story does not mention the frequency of the test’s false positives or false negatives, both of which could have serious consequences for the patient.

Does the story seem to grasp the quality of the evidence?

Not Satisfactory

The article refers to an article "recently" published in the Journal of Clinical Lipidology. It does not name the article or specify the date. 

It appears the study is a paper published in October 2007 based on data collected for the Framingham Offspring Study. This is an observational study, not a clinical trial. 


Does the story commit disease-mongering?

Not Satisfactory

The article implies that people who are ignorant about their LDL particle numbers cannot know their true heart disease risk. This can make people needlessly fearful that they need to have this test.

Does the story use independent sources and identify conflicts of interest?

Not Satisfactory

The article quotes only one source, William Cromwell, the former chief medical officer of LipoSource, which markets the LipoProfile test.

While the story says that Cromwell no longer has financial interest in the company, his co-author on the published study is an executive with LipoSource. This calls into question the reporter’s assertion that Cromwell "no longer has a relationship with" his former employer. 

Under the circumstances, the lack of a clearly independent source is a serious failing.  

Does the story compare the new approach with existing alternatives?

Not Satisfactory

The story does not describe how heart disease risk can be assessed and managed by means other than using the LipoSource test.

Does the story establish the availability of the treatment/test/product/procedure?

Not Satisfactory

The article fails to report how and under what conditions the LipoProfile test is available.

Does the story establish the true novelty of the approach?

Not Satisfactory

The article implies the LipoProfile test is a novel method of identifying otherwise hidden heart disease risk using lipid analysis.

In fact, there are several tests available and under development that seek to link heart disease risk with a variety of lipid measures other than LDL and HDL numbers. 

Does the story appear to rely solely or largely on a news release?

Not Applicable

The company’s most recent press release was issued on March 28. It’s not clear whether it triggered this story. No other media have written about the test or the company recently.

Total Score: 0 of 9 Satisfactory


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