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Bone Proteins Costly In Surgery, Study Says

Rating

2 Star

Bone Proteins Costly In Surgery, Study Says

Our Review Summary

This story about spinal fusion surgeries that use bone-growth proteins [BMPs] pursues an important cost angle more aggressively than some other stories we saw on this same study.  But it missed an important point: 

The current study does not have the power to resolve the long-standing question about whether the higher short-term costs of BMPs are offset by lower long-term follow-up care. All it does is confirm that short-term costs are higher.

The story mentions the lack of long-term data as a mere caveat.

If you strip down the study you see a few interesting observations: About a quarter of spinal fusions now use BMPs. Surgeries on the inside of the spine near the neck cause breathing problems. BMP surgeries appear to be used more often in certain populations, but limitations in the data make any conclusions about disparities premature.

That isn’t much to wrap a story around.

A reader seeing a story about the cost or complications of BMPs has a broader set of questions:

Does the [initially] more expensive technique produce better outcomes? Which patients are best suited to this surgery? What really is the long-term picture? Is this yet another case of an expensive new technique making a company rich when an established treatment is just as good or better?

And what about the angle that most spinal fusion surgeries are deemed unnecessary anyway?

This study, a valuable piece of medical research, nonetheless doesn’t address any of those fundamental questions. And neither did the story.

Criteria

Does the story adequately discuss the costs of the intervention?

Not Satisfactory

The story fails spectacularly with the issue of costs.

First, it’s not clear why the story focuses primarily on the 11- to 41-percent higher in-hospital costs of BMP–the study’s findings on prevalence and complication rates are at least as significant. 

Yet despite the story’s focus on costs, the story lacks basic reporting on them. The story fails to say how much the surgery costs, how big that 11 to 41 percent premium really is, and who pays for it. And in whose pocket that extra spending winds up in.  

As it happens, the journal study itself includes these details: The BMP product costs about $4,000. For anterior cervical fusion, the surgery without BMP cost about $31,000. With BMP, about $46,000. 

But it gets worse.

As the story itself explains, the issue of total BMP costs has been controversial since the technology’s inception because [as BMP makers suggest] patients who get BMP surgery may require less treatment over the course of their lives than their peers. Despite the interested source, it’s a legitimate argument worth exploring. 

And yet: As the authors of the journal article themselves explain, this study did not follow patients over time and therefore lacked the power to speak to the question of total costs at all. Its findings about in-hospital costs are useful but not in any way conclusive.

In other words: the story focuses on the findings of higher costs of BMP despite the fact that the study cannot resolve the question of total costs–which, from a public health perspective, is the only one that counts.

Does the story adequately quantify the benefits of the treatment/test/product/procedure?

Not Satisfactory

The JAMA study is silent on whether BMP "works"–which is to say, whether BMP improves outcomes, quality of life, morbidity or mortality. 

No harm in that: This piece of research is designed to look only at prevalence, complications and costs.

But the news story’s shorthand conclusions–that the surgery is common, costly and linked to certain complications–begs the question of whether better outcomes outweigh those negatives. It’s hard to imagine what kind of reader would not want to know the answer. 

Certainly at least some comparative outcome data exists. [Or if not, then that is worth mentioning.] The reporter didn’t even mention the issue.   

Does the story adequately explain/quantify the harms of the intervention?

Not Satisfactory

In the final paragraph, the story mentions that BMP is linked to more complications, particularly difficulty swallowing in surgeries done high on the spine.

But the story didn’t explain how big were the potential harms.  According to the results of the study, the use of BMP in anterior cervical fusion is associated with a 51.4% higher complication rate compared to patients who did not receive BMP (7.09% vs. 4.68%, respectively).  However, these data were not presented in the story.

Does the story seem to grasp the quality of the evidence?

Not Satisfactory

The story fails to provide necessary caveats to help readers understand the study’s limitations.

In fact, the story mentions only the positive attributes of the study: That the data drew on a "broad U.S. sample of 328,000 spine surgeries" and included information from 20 percent of the nation’s hospitals. 

But the study has significant limitations: It used existing data from previous surgeries. It did not follow individual patients over time. It did not include information about subsequent outcomes, additional treatments, quality of life, morbidity or mortality. 

The story should have stated these shortcomings plainly. 

Does the story commit disease-mongering?

Satisfactory

The story does not engage in disease mongering.

Does the story use independent sources and identify conflicts of interest?

Not Satisfactory

The study uses only one live source, the study’s lead author. This is insufficient.

One or two additional voices would have been able to put these findings in context and help readers understand what they might mean. 

Having said that, the reporter does get extra points for trying to contact a researcher with clear economic motivations to explain his conclusions, which differ from the current study’s.

Does the story compare the new approach with existing alternatives?

Not Satisfactory

The story doesn’t explain how someone with serious chronic back pain becomes a candidate for surgery, and then how he or she becomes a candidate for BMP.

A paragraph that explains the available treatment options at various stages of the condition would have been very useful.

This is particularly true since a long-standing question about spinal fusion surgery, regardless of technique, is whether it is overused and potentially harmful.  

Does the story establish the availability of the treatment/test/product/procedure?

Satisfactory

The story states correctly that about 25 percent of spinal fusion surgeries use bone-growth proteins [BMPs].

Does the story establish the true novelty of the approach?

Satisfactory

The story clearly cites usage data since 2002, so it’s clear this is not a just-unwrapped product or procedure.

Does the story appear to rely solely or largely on a news release?

Satisfactory

Given the history and the potential conflict of interest question raised in the story, it is safe to assume that it did not rely on a news release.

Total Score: 4 of 10 Satisfactory

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