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IUD Proposed to Treat Uterine Cancer


5 Star

IUD Proposed to Treat Uterine Cancer

Our Review Summary

This story carefully reports on these results, with appropriate caveats that emphasize the small size of the study, the preliminary nature of the results and narrow patient population (those with pre-cancerous lesions or early-stage cancer). It quotes several independent experts and  discloses potential conflict of interest. The story could have been improved by mentioning the cost of the IUD and insurance coverage.


Why This Matters

The progestin-containing IUD (brand name Mirena) is a highly effective, well-tolerated form of birth control. Pathology studies have also shown that the IUD can cause reversal of cellular changes, known as hyperplasia, in the lining of the uterus (enodmetrium) that could later lead to certain kinds of endometrial cancer.Oral progestins are an established treatment for endometrial hyperplasia and have also been used in some cases of endometrial cancer in younger women. Targeting progesterone release directly to the uterine lining through the IUD presents a potential advance in effectiveness and tolerability of treatment, while preserving fertility.

The primary treatment for endometrial cancer is hysterectomy, or surgical removal of the uterus. However, for some women, particularly younger women who wish to preserve their fertility, the idea of a non-surgical alternative, is welcome news. A small study was published in this week’s Annals of Oncology followed 20 women with hyperplasia and 14 women with early-stage endometrial cancer who had a progestin-IUD implanted. Almost all (95%) of those with hyperplasia experienced reversal, while about half (57%) of those with early-stage endometrial cancer did.


Does the story adequately discuss the costs of the intervention?

Not Satisfactory

The story does not mention any costs of the IUD or other treatments.

Does the story adequately quantify the benefits of the treatment/test/product/procedure?


The story quantifies the benefits of the progestin IUD in several ways.

Does the story adequately explain/quantify the harms of the intervention?


The story accurately notes that the study reported no adverse effects. The study’s authors reported only on adverse effects that were sufficient to require suspension of treatment.

Does the story seem to grasp the quality of the evidence?


The story provides important details about the current study that help the reader evaluate the strength of the evidence. It even emphasizes that the new treatment approach is "still uNPRoven".

Does the story commit disease-mongering?


The story does not exaggerate the seriousness or prevalence of uterine cancer and is clear to point out that this treatment is only appropriate for a small subset of cases.

Does the story use independent sources and identify conflicts of interest?


The story quotes several independent experts and notes that none had a conflict of interest.

Does the story compare the new approach with existing alternatives?


The story compares the progestin IUD with systemic hormones and hysterectomy

Does the story establish the true novelty of the approach?


The story clearly states that the Mirena IUD is not a new idea, but using it to treat early-stage endometrial cancer is relatively novel.

Does the story appear to rely solely or largely on a news release?


Because the story quotes several independent experts, the reader can assume that the story did not rely on a press release as the sole source of information.

Total Score: 9 of 10 Satisfactory


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