The introduction of Gleevec represented a major advance in the treatment of chronic myelogenous leukemia (CML). This story reports on a study printed in Nature Medicine describing 10 patients who developed heart failure while taking the drug. The authors of the study suggest that this drug needs to be thoroughly evaluated to quantify the magnitude of the heart risk.
This does not adequately describe the nature of the existing evidence, which is very preliminary. Although the story focuses on the heart risks associated with Gleevec, it does not adequately describe the harms of treatment. What other side effects are there? How common are they? How common is heart damage?
Although the main focus of the story is on new reports of toxicity from Gleevec, the story still allowed some promotional claims to enter into the story. (e.g., “Gleevec is a wonderful drug and patients with these diseases need to be on it. It’s a lifesaving drug for sure” and “Novartis said Force’s work does not change ‘the positive benefit/risk ratio of Glivec for thousands of patients being treated for cancer and other life-threatening diseases.’ “) Yet there are no data given to back up these claims of benefit.
The story also does not mention alternative treatments. The story should have explain why Gleevec is consider to be better and provide some perspective as to whether it still would if indeed heart failure is found to be a significant side effect. The story never mentions the cost of Gleevec, which is very expensive. These new reports on side effects may decrease the cost-effectiveness of the drug. Cost should not have been left out of the story.
Furthermore, the story only quotes the author of the study and a statement from Novartis. The story should have quoted other, independent researchers or clinicians who could have provided additional perspectives.
The story never mentions the cost of Gleevec, which is very expensive. These new reports on side effects may decrease the cost-effectiveness of the drug. Cost should not have been left out of the story.
Although the main focus of the story is on new reports of toxicity from Gleevec, the story still allowed some promotional claims to enter into the story. (e.g., “Gleevec is a wonderful drug and patients with these diseases need to be on it. It’s a lifesaving drug for sure” and “Novartis said Force’s work does not change ‘the positive benefit/risk ratio of Glivec for thousands of patients being treated for cancer and other life-threatening diseases.’ “) Yet there are no data given to back up these claims of benefit.
Although the story focuses on the heart risks associated with Gleevec, it does not adequately describe the harms of treatment. What other side effects are there? How common are they? How common is heart damage?
The story does not adequately describe the nature of the existing evidence. It does not provide evidence from prior studies on heart failure.
The story does not engage in disease mongering.
The story only quotes the author of the study and a statement from Novartis. The story should have quoted other, independent researchers or clinicians who could have provided additional perspectives.
The story does not mention alternative treatments. The story should have explained why Gleevec is considered to be better and provided some perspective as to whether it still would be if indeed heart failure is found to be a significant side effect.
The availability of the drug is clear in this story.
The story states that Gleevec is an existing therapy for leukemia.
There is no way to know if the story relied on a press release as the sole source of information.
Systematic, Criteria-Driven
We’ve written about the hype of liquid biopsies for years (see link in comment below). And now this…. https://www.statnews.com/2022/01/12/medicare-shouldnt-cover-liquid-biopsies-early-cancer-detection/
Case counts still matter. “(There) are stories that may not be told adequately if only hospitalizations and deaths are emphasized.” @garyschwitzer interviewed by @dbauder of @AP. https://apnews.com/article/omicron-changing-news-outlets-covid-data-da9272f7c4c8a109c3bfb56bed9e9c76
My friend Gary @garyschwitzer wrote to his city council representative in a Minnesota town about a Viva Las Vegas event scheduled for January.
The response he got seems to perfectly capture where we are now.
https://www.healthnewsreview.org/2021/12/2021-ends-with-covid-craziness-in-sports-and-politics/
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