The story reports recent evidence that anti-depressants given in conjunction with mood stabilizing drugs (such as lithium) do not significantly improve depression or exacerbate mania in bipolar patients. The story suggests that anti-depressants are over-prescribed to patients with bipolar disorder; therefore, there is a suggestion that less treatment with anti-depressants is better.
The story appropriately describes the design and some of the quantitative results of a randomized, placebo-controlled, double-blind study conducted by The Systemic Treatment Enhancement Program for Bipolar Disorder and published in the New England Journal of Medicine. The story includes information from an author of the study, as well as from a researcher not involved in the study, but who specializes in bipolar treatment. The story notes that the study was sponsored by the National Institute of Mental Health.
The story mentions the potential harm of triggering a manic episode and reports (accurately) that there was no observed difference. The story could have gone further and discussed common harms from antidepressants stacked up against this finding of no benefit – strong incentive to stop giving antidepressant to bipolar disorder.
The story also could have discussed other options (such as psychosocial treatments) and whether any of these treatments work.
Overall, though, a very complete story – and in only 406 words.
The story does not mention the cost of medication to treat bipolar disorder; however, the story and evidence from the study cited are advocating fewer anti-depressant medications. So cost seems less of an issue in this case. However, the story missed an opportunity to talk about the cost of bipolar disease (90 million work loss days annually in the U.S) and associated health care/treament costs.
The story provides some absolute data on patients' self-reported recoveries and mood. At 26 weeks follow-up, of 366 bipolar patients, 27% of patients who took a mood stabilizer and placebo experienced 8 weeks of of positively improved mood, but did not become manic; 23.%5 of patients receiving anti-depressants and a mood stabilizer achieved the same 8-week period of improved mood.
The story mentions the potential harm of triggering a manic episode and reports (accurately) that there was no observed difference in the groups studied. The story could have gone further and discussed common harms from antidepressants stacked up against this finding of no benefit – strong incentive to stop giving antidepressants for bipolar disorder.
The story describes the study design and provides some quantitative evidence from the study of bipolar patients who were given placebos or anti-depressant medications with mood stabilizing drugs.
The story does not engage in disease mongering. The story lists the estimated prevalence of bipolar disorder in the U.S.
The story includes information from an author of the study cited, as well as from a researcher not involved in the study, but who specializes in bipolar treatment. The story mentions that the study was sponsored by the National Institute of Mental Health, and the authors disclose the potential conflicts.
The story notes, in passing, that mood stabilizing drugs are used. It doesn't say anthing about other options (such as psychosocial treatments) and whether any of these treatments work.
It's clear from the story that the drugs in question are commonly prescribed and available.
The story reports on a recent evidence that anti-depressants given in conjunction with mood stabilizer drugs do not significantly improve depression in bipolar patients. This was a novel research question and finding.
There was independent reporting and no evidence the information in this story is taken directly from a press release.
Systematic, Criteria-Driven
We’ve written about the hype of liquid biopsies for years (see link in comment below). And now this…. https://www.statnews.com/2022/01/12/medicare-shouldnt-cover-liquid-biopsies-early-cancer-detection/
Case counts still matter. “(There) are stories that may not be told adequately if only hospitalizations and deaths are emphasized.” @garyschwitzer interviewed by @dbauder of @AP. https://apnews.com/article/omicron-changing-news-outlets-covid-data-da9272f7c4c8a109c3bfb56bed9e9c76
My friend Gary @garyschwitzer wrote to his city council representative in a Minnesota town about a Viva Las Vegas event scheduled for January.
The response he got seems to perfectly capture where we are now.
https://www.healthnewsreview.org/2021/12/2021-ends-with-covid-craziness-in-sports-and-politics/
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