The focus of the story is on one potential serious harm of anti-depressants in children, i.e. increased risk of suicidality. The story also discusses the harm of not taking medication. Newly published observational data suggests there may be an association between the decrease in anti-depressant prescriptions and an increase in pediatric suicides. A big problem here is using expert comments which are unsubstantiated for describing harms. There is a comment about increased suicide risk vs. increased suicide untreated (but the expert didn’t cite credible references to back the numbers). There is also no discussion of the weak observational data presented. It is not put into context well with the meta-analysis of randomized clinical trials showing a small benefit of antidepressants in teens and a small increase in suicide risk when on antidepressants. None of the authors or experts did a good job (or perhaps it was the reporter) of contextualizing the results.
The story does not provide much quantitative evidence on the benefits or harms of treatment in children and adolescents. The story should have mentioned other side effects of antidepressants such as nausea, sleep disturbance or interactions with other medications. Additionally, the cost of anti-depressant medications are not mentioned. Cost of generic Prozac is about $16/month. Branded versions are about $80-120/month.
The patient’s anecdote as the lead for the story suggests that taking anti-depressants is a panacea and thus could effectively treat and prevent relapses of major depression and/or homicidal or suicidal thoughts and behavior. This is not always the case, though, these medications do help many people, especially to engage socially and in psychotherapy. Psychotherapy or other forms of behavioral therapy– in conjunction with medication-– is often more effective than medication alone, but these treatments are not mentioned.
Lastly, the story does not engage in disease mongering, per se, but, to say the black box warning is "killing kids" may be an overstatement as we only have one year of observational data, and there may be other variables involved in the increased rate of pediatric suicides.
The cost of anti-depressant medications are not mentioned. Cost of generic Prozac is about $16/month. Branded versions are about $80-120/month.
The story does not provide much quantitative evidence on the benefits or harms of treatment. The story notes the 50% drop in prescriptions and the 18% increase in suicides, but we are given no context for these statistics. Additionally, the story does not provide data on the risk/benefits of anti-depressants in children and adolescents. Recent meta-analysis in JAMA should have been cited.
The focus of the story is on one potential serious harm of anti-depressants in children, i.e. increased risk of suicidality. The story also discusses the harm of not taking medication. Early data suggests there may be an association between the decrease in anti-depressant prescriptions and an increase in pediatric suicides. The link between the two is unconfirmed and there may be other variables as to why teen suicide has increased 18% between 2003 and 2004. The story should have mentioned other side effects of antidepressants such as nausea, sleep disturbance or interactions with other medications. A big problem here is using expert comments – unsubstantiated – for describing harms. There is a comment about increased suicide risk vs. increased sucicide untreated (but the expert didn’t cite credible references to back the numbers)
The story does discuss the correlation between increased teen suicides and the decrease in prescriptions for anti-depressants. There is no discussion of the weak observational data presented. It is not put into context well with the meta-analysis of randomized clinical trials showing a small benefit of antidepressants in teens and a small increase in suicide risk when on antidepressants. None of the authors or experts did a good job (or perhaps the reporter) of contextualizing the results.
The story does not engage in disease mongering. However, to say the black box warning is "killing kids" may be an overstatement as study data is only for one year, and there may be other variables involved in the increased rate of pediatric suicides. The story would be improved by giving information on frequency of the depression and/or suicide in this group.
The story interviews several psychiatrists and researchers not affiliated with the recent study about anti-depressants and suicidality in pediatric depression. The story also provides perspective from a patient’s family and a member of the FDA who argued against the black box warning on certain anti-depressants. The story properly notes that Eli Lilly, maker of commonly prescribed anti-depressants, funded the recent research.
The patient’s anecdote as the lead for the story suggests that taking anti-depressants is a panacea and thus would prevent major depression and/or homicidal or suicidal behavior. This is not always the case, though these medications do help many people, especially to engage more fully in psychotherapy or socially. Psychotherapy or other forms of behavioral therapy– in conjunction with medication-– is often more effective than medication alone, but these treatment are not mentioned.
The story notes that anti-depressants are being prescribed to children and adolescents less frequently due to an FDA black box warning about increased suicidality with certain medications. Apprehension about the increased risk of suicide with these medications may make the medications unavailable to those who might benefit from them.
SSRIs (selective serotonin reuptake inhibitors) are not new –they have been available since the 1980s–however, the side effect profile of these medications in younger patients is still not fully understood. The current data are useful, although the association between suicide and antidepressant use is not particularly novel.
There are multiple sources and independent reporting. The story does not appear to rely on a press release for information.
Systematic, Criteria-Driven
Monday at #ADA2021, an infectious disease epidemiologist, a journalist, and a researcher shared perspectives on communication of risk in the era of COVID-19: http://ow.ly/ROfR30rMeE7 @AstleyCM @garyschwitzer @berthahidalgo @ADA_DiabetesPro
Shoutouts to @susan_bewley @drkevinknopf @MichaelBaum11 in this call for more than fawning coverage from press releases for these kinds of stories.
Also, linked history inside goes back 5 years just on Grail apparently trying to become Holy Grail. https://twitter.com/garyschwitzer/status/1408849696416841731
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