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Medical Daily story on stem cells for stroke needed injection of independent viewpoints

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3 Star

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Stem Cells May Safely Restore Motor Function In Patients Suffering From Disabilities After Stroke

Our Review Summary

Side profile elderly man solving problem thinkingDrawn substantially from a feature-style news release issued by Stanford University’s School of Medicine, this story describes results of a trial in which modified human stem cells were injected into the brains of so-called “chronic” stroke patients.

The results, which study authors called promising, showed the injections were safe. The stem cells–as expected–survived only briefly, but the researchers report that there were “clinically meaningful results” in which some patients (it’s unclear how many) recovered “significant” motor function.

The story states the total number of patients (18), their age range (average age was 61), but it’s missing hard information about the range of specific improvements, along with any interviews from researchers independent of this study or medical center.

 

Why This Matters

An estimated 800,000 people in the U.S. experience an ischemic stroke each year, and most of them have permanent motor deficits unless treated with drugs within a few hours of the stroke. Given that this pilot safety study showed improvements in patients whose first-ever strokes occurred from six months to three years before treatment with mesenchymal stem cell injections, millions of people with stroke disability could potentially realize some restored function if the current research is borne out in further studies.

Criteria

Does the story adequately discuss the costs of the intervention?

Not Applicable

Because this story involved an experimental therapy in an early phase trial, formulating a probable cost of the treatment is premature. The story would have been strengthened, perhaps, by some indication of what stroke care and disability costs in lost productivity and health care expenses in the U.S.

Does the story adequately quantify the benefits of the treatment/test/product/procedure?

Not Satisfactory

The story is clearly upbeat about the promise of the therapy and uses a great deal of positive language from the news release. But the story did not really quantify the results in a way that would give readers a sensible picture of just how many of the 18 could “walk again” and what exactly the metrics used to assess results consist of.

Does the story adequately explain/quantify the harms of the intervention?

Satisfactory

The article duly noted side effects.  It’s worth pointing out that the study only followed patients for about a year, and long-term effects are unknown and could be more severe.

Does the story seem to grasp the quality of the evidence?

Not Satisfactory

The article does not adequately describe the quality of evidence. We’re told there was a trial, but not that it was done on a small number of patients chiefly to establish safety.

The story would have been stronger on this criteria if it had, for example, used this researcher’s quote from the news release:

“This was just a single trial, and a small one. It was designed primarily to test the procedure’s safety.”

Does the story commit disease-mongering?

Satisfactory

No mongering here.

Does the story use independent sources and identify conflicts of interest?

Not Satisfactory

As noted above, this article appears to have been drawn substantially if not exclusively from the news release, although the writer appears to have interviewed the principal investigator; but it offers not a single source outside of the investigators who presumably approved the news release issued by Stanford.

There is disclosure about industry funding in the news release, but none at all in the article. The article would have gone a long way to put credibility and context into a genuinely promising experimental therapy if it had sought comment from an independent stem cell therapy researcher.

Does the story compare the new approach with existing alternatives?

Not Satisfactory

Although the article mentions there are “therapies” that help after a stroke, it does not mention what these are, how often they succeed, how often they fail, or their costs.

Does the story establish the availability of the treatment/test/product/procedure?

Satisfactory

The article notes that the investigators are planning a larger trial of the procedure.

Does the story establish the true novelty of the approach?

Satisfactory

We’ll give this a Satisfactory rating here because the article does make the point that the stem cell therapy trial in question does demonstrate safety and some efficacy; and it also notes that the benefits were detected regardless of the severity, duration, or location of the stroke in the test population.

And it does well by mentioning that previous research showed the stem cells used can “treat” brain cell damage caused by loss of oxygen, essentially what happens in an ischemic stroke. The article could have done better by saying whether that past research was done in lab-grown cells or in animals.

Does the story appear to rely solely or largely on a news release?

Satisfactory

Because the story includes an interview with the lead researcher–with quotes not found in the news release–this is Satisfactory. However, that’s about the only information in the story not found in the news release, so this is a barely passing scenario.

Total Score: 5 of 9 Satisfactory

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